Topical drug delivery represents the most direct and effective therapeutic approach for dermatological disorders, offering localized drug action, reduced systemic exposure, and enhanced patient compliance. However, conventional topical formulations face significant limitations including poor skin penetration, inadequate drug retention, and suboptimal therapeutic outcomes. The stratum corneum barrier restricts drug permeation, necessitating innovative delivery strategies. Advanced nanocarrier systems including liposomes, niosomes, solid lipid nanoparticles, nanostructured lipid carriers, polymeric nanoparticles, and nanogels have emerged as promising platforms for enhanced dermatological therapeutics. These nanosystems improve drug stability, facilitate controlled release, enhance skin penetration through various mechanisms, and enable targeted delivery to specific skin layers. Physical enhancement techniques such as microneedles, iontophoresis, and sonophoresis further augment drug permeation. Clinical applications span inflammatory conditions including psoriasis and atopic dermatitis, infectious diseases, skin cancers, and pigmentation disorders. This review comprehensively examines conventional and novel topical formulations, nanocarrier platforms, penetration enhancement mechanisms, therapeutic applications across dermatological conditions, and safety and regulatory considerations. Despite promising preclinical results, clinical translation remains challenging due to scalability concerns, regulatory requirements, and cost-effectiveness considerations. Future directions include stimuli-responsive systems, personalized formulations, and integration of diagnostic and therapeutic functions for precision dermatology.