The goal of this study was to assess the efficacy of a method based on the formulate of polymeric nanoparticles as an innovative formulation of Cabazitaxel with enhanced therapeutic efficacy. Cabazitaxel has low solubility and permeability, which result in limited and variable bioavailability; its low stability makes it difficult to develop stable aqueous liquid formulations. The Cabazitaxel Polymeric nanoparticles were created using the precipitation method. The numerous formulations with varied drug-polymer were analyzed and improved. Particle size, surface morphology by SEM, drug excipient compatibility by FTIR, and In-vitro drug release experiments were used to characterize the produced nanoparticles. The formulation with the best encapsulation efficiency was (F-3). A drug encapsulation effectiveness of up to 83.56 % has been attained in this study. It was discovered that the efficiency of encapsulation improved along with the polymer content. According to the results of the current investigation, the manufacture of Cabazitaxel Polymeric nanoparticles can be done using a precipitation process followed by sonication.