Abstract

The present research work was aimed at the development and characterization of a liposomal drug delivery system for Vincristine, a potent chemotherapeutic agent widely used in the treatment of haematological malignancies and solid tumors. Conventional Vincristine formulations are associated with dose-limiting neurotoxicity, rapid systemic clearance, and poor selectivity toward tumor tissues. To overcome these drawbacks, liposomes were formulated as nanocarriers to enhance therapeutic efficacy and reduce adverse effects. Liposomes were prepared using the thin-film hydration method followed by sonication to obtain uniform vesicles. Drug and lipids compatibility determined by using FTIR. The prepared formulations were evaluated for vesicle size, encapsulation efficiency, and in vitro drug release profile. Morphological characterization was carried out using Scanning electron microscopy (SEM) to confirm the spherical shape and Nano-range distribution of vesicles. Optimized formulations showed high encapsulation efficiency, in vitro drug release, and favorable stability under storage conditions. The findings suggest that the developed Vincristine liposomal system could serve as a promising nanocarrier for targeted and sustained cancer therapy with minimized systemic toxicity.